|Pope Sixtus IV|
|Role:||Leader of the Catholic Church|
|First Appearance:||The Hanged Man|
|Portrayed by:||James Faulkner|
He visited the Vatican Archives in order to discuss their future plans to push against the Medici clan with Francesco Pazzi and the curator, Lupo Mercuri. Girolamo arrived with his agent, Lucrezia Donati, whom the Pope was impressed with. He decided that they needed to deal with Leonardo da Vinci who seemed to be causing too much trouble and was helping Lorenzo Medici in a damaging way.